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Crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from Thermus Thermophilus HB8

Source organism: Thermus thermophilus HB8
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 5.3.3.10: 5-carboxymethyl-2-hydroxymuconate Delta-isomerase

Reaction catalysed:
5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate
Systematic name:
5-carboxymethyl-2-hydroxymuconate Delta(2),Delta(4)-2-oxo,Delta(3)-isomerase
Alternative Name(s):
  • 5-carboxymethyl-2-hydroxymuconic acid isomerase
  • CHM isomerase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01557
Domain description: Fumarylacetoacetate (FAA) hydrolase family
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
The deposited structure of PDB entry 2dfu contains 4 copies of Pfam domain PF01557 (Fumarylacetoacetate (FAA) hydrolase family) in Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. Showing 1 copy in chain A.

PF10370
Domain description: Rv2993c-like, N-terminal
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
The deposited structure of PDB entry 2dfu contains 4 copies of Pfam domain PF10370 (Rv2993c-like, N-terminal) in Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036663
Domain description: Fumarylacetoacetase-like, C-terminal domain superfamily
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
IPR011234
Domain description: Fumarylacetoacetase-like, C-terminal
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
IPR018833
Domain description: Rv2993c-like, N-terminal
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase

Structure domains

CATH CATH domains
3.90.850.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Fumarylacetoacetate hydrolase; domain 2
Homology: Fumarylacetoacetase-like, C-terminal domain
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
The deposited structure of PDB entry 2dfu contains 4 copies of CATH domain 3.90.850.10 (Fumarylacetoacetate hydrolase; domain 2) in Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. Showing 1 copy in chain A.
2.30.30.370
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: FAH
Occurring in:
  1. Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
The deposited structure of PDB entry 2dfu contains 4 copies of CATH domain 2.30.30.370 (SH3 type barrels.) in Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. Showing 1 copy in chain A.

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