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Crystal structure of a multidrug transporter reveal a functionally rotating mechanism

X-ray diffraction
3.3Å resolution
PDB entry 2dr6 coloured by chain, front view.
PDB entry 2dr6 coloured by chain, side view.
PDB entry 2dr6 coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Multidrug efflux pump subunit AcrB
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Multimeric state: homo trimer
Accessible surface area: 115984.62 Å2
Buried surface area: 19198.5 Å2
Dissociation area: 5,927.84 Å2
Dissociation energy (ΔGdiss): 56.32 kcal/mol
Dissociation entropy (TΔSdiss): 17.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151927
Homo trimeric assembly 1 of PDB entry 2dr6 coloured by chemically distinct molecules, front view.
Homo trimeric assembly 1 of PDB entry 2dr6 coloured by chemically distinct molecules, side view.
Homo trimeric assembly 1 of PDB entry 2dr6 coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 3
Symmetry : C3
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3DComplex & QSbio predictionx
No. subunits : 3
Symmetry : C3
Evidence : quaternary structure geometry is similar to that of 3w9i_1 (70% id)

Macromolecules

Multidrug efflux pump subunit AcrB
Chains: A, B, C
Length: 1053 amino acids
Theoretical weight: 114.22 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P31224 (Residues: 1-1049; Coverage: 100%)
Gene names: JW0451, acrB, acrE, b0462
Pfam: AcrB/AcrD/AcrF family
InterPro:
CATH:
Multidrug efflux pump subunit AcrB in PDB entry 2dr6, assembly 1, front view.
Multidrug efflux pump subunit AcrB in PDB entry 2dr6, assembly 1, side view.
Multidrug efflux pump subunit AcrB in PDB entry 2dr6, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P31224  
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