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PFKFB3 in complex with ADP and PEP

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: motor behavior
Cellular component: cytosol

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EC 3.1.3.46: Fructose-2,6-bisphosphate 2-phosphatase

Reaction catalysed:
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Systematic name:
Beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase
Alternative Name(s):
  • D-fructose-2,6-bisphosphate 2-phosphohydrolase
  • Fructose-2,6-bisphosphatase

EC 2.7.1.105: 6-phosphofructo-2-kinase

Reaction catalysed:
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
Systematic name:
ATP:beta-D-fructose-6-phosphate 2-phosphotransferase
Alternative Name(s):
  • 6-phosphofructo-2-kinase (phosphorylating)
  • 6-phosphofructose 2-kinase
  • ATP:D-fructose-6-phosphate 2-phosphotransferase
  • Fructose 6-phosphate 2-kinase
  • Phosphofructokinase 2

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00300
Domain description: Histidine phosphatase superfamily (branch 1)
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
The deposited structure of PDB entry 2dwo contains 1 copy of Pfam domain PF00300 (Histidine phosphatase superfamily (branch 1)) in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. Showing 1 copy in chain A.

PF01591
Domain description: 6-phosphofructo-2-kinase
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
The deposited structure of PDB entry 2dwo contains 1 copy of Pfam domain PF01591 (6-phosphofructo-2-kinase) in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003094
Domain description: Fructose-2,6-bisphosphatase
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
IPR013078
Domain description: Histidine phosphatase superfamily, clade-1
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
IPR029033
Domain description: Histidine phosphatase superfamily
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
IPR001345
Domain description: Phosphoglycerate/bisphosphoglycerate mutase, active site
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
IPR013079
Domain description: 6-phosphofructo-2-kinase
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Structure domains

CATH CATH domains
3.40.50.1240
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Phosphoglycerate mutase-like
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
The deposited structure of PDB entry 2dwo contains 1 copy of CATH domain 3.40.50.1240 (Rossmann fold) in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. Showing 1 copy in chain A.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
The deposited structure of PDB entry 2dwo contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. Showing 1 copy in chain A.

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