Structure analysis

Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NAD and Inhibitor L-serine

X-ray diffraction
1.8Å resolution
Source organism: Thermus thermophilus HB8
Assemblies composition:
homo dimer (preferred)
homo hexamer
homo tetramer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 33895.81 Å2
Buried surface area: 13841.07 Å2
Dissociation area: 3,608.59 Å2
Dissociation energy (ΔGdiss): 60.05 kcal/mol
Dissociation entropy (TΔSdiss): 15.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-177922
Assembly 2
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Multimeric state: homo hexamer
Accessible surface area: 91488.95 Å2
Buried surface area: 51743.53 Å2
Dissociation area: 5,283.39 Å2
Dissociation energy (ΔGdiss): 35.91 kcal/mol
Dissociation entropy (TΔSdiss): 33.18 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-177924
Assembly 3
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Multimeric state: homo tetramer
Accessible surface area: 64393.27 Å2
Buried surface area: 31102.33 Å2
Dissociation area: 1,761.6 Å2
Dissociation energy (ΔGdiss): 7.39 kcal/mol
Dissociation entropy (TΔSdiss): 15.7 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-177923

Macromolecules

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