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Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative

X-ray diffraction
2.7Å resolution
PDB entry 2f0y coloured by chain, front view.
PDB entry 2f0y coloured by chain, side view.
PDB entry 2f0y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein farnesyltransferase complex
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Multimeric state: hetero dimer
Accessible surface area: 27660.06 Å2
Buried surface area: 8784.98 Å2
Dissociation area: 3,541.02 Å2
Dissociation energy (ΔGdiss): 29.89 kcal/mol
Dissociation entropy (TΔSdiss): 14.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155932
Complex Portal ID: CPX-2165

Macromolecules

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Chain: A
Length: 379 amino acids
Theoretical weight: 44.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49354 (Residues: 1-379; Coverage: 100%)
Gene name: FNTA
Pfam: Protein prenyltransferase alpha subunit repeat
InterPro: Protein prenyltransferase, alpha subunit
CATH: Protein prenylyltransferase
SCOP: Protein prenylyltransferase
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 2f0y, assembly 1, front view.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 2f0y, assembly 1, side view.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 2f0y, assembly 1, top view.
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Protein farnesyltransferase subunit beta
Chain: B
Length: 437 amino acids
Theoretical weight: 48.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49356 (Residues: 1-437; Coverage: 100%)
Gene name: FNTB
Pfam: Prenyltransferase and squalene oxidase repeat
InterPro:
CATH: Glycosyltransferase
SCOP: Protein prenyltransferases
Protein farnesyltransferase subunit beta in PDB entry 2f0y, assembly 1, front view.
Protein farnesyltransferase subunit beta in PDB entry 2f0y, assembly 1, side view.
Protein farnesyltransferase subunit beta in PDB entry 2f0y, assembly 1, top view.
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