EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
GO terms
Biochemical function:
- ubiquitin ligase activator activity
- RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
- RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
- phosphoprotein binding
- phosphothreonine residue binding
- phosphoserine residue binding
- tau protein binding
- GTPase activating protein binding
- mitogen-activated protein kinase kinase binding
- cis-trans isomerase activity
- beta-catenin binding
- protein binding
- cytoskeletal motor activity
- peptidyl-prolyl cis-trans isomerase activity
Biological process:
- negative regulation of cell motility
- negative regulation of amyloid-beta formation
- regulation of protein localization to nucleus
- positive regulation of canonical Wnt signaling pathway
- regulation of primary metabolic process
- cellular response to hypoxia
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of SMAD protein signal transduction
- regulation of macromolecule metabolic process
- protein stabilization
- synapse organization
- microtubule polymerization
- positive regulation of transcription by RNA polymerase II
- positive regulation of GTPase activity
- negative regulation of protein catabolic process
- regulation of cytokinesis
- positive regulation of protein binding
- negative regulation of protein binding
- regulation of protein stability
- negative regulation of transforming growth factor beta receptor signaling pathway
- neuron differentiation
- regulation of gene expression
- regulation of mitotic nuclear division
- protein targeting to mitochondrion
- positive regulation of protein phosphorylation
- regulation of protein phosphorylation
- response to hypoxia
- protein peptidyl-prolyl isomerization
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR023058
Domain description:
Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
Occurring in:
Occurring in:
CATH domains
SCOP annotations
