Assemblies
Assembly Name:
Coagulation factor VIIa - tissue factor complex
Multimeric state:
hetero trimer
Accessible surface area:
22092.08 Å2
Buried surface area:
5502.97 Å2
Dissociation area:
1,436.27
Å2
Dissociation energy (ΔGdiss):
3.63
kcal/mol
Dissociation entropy (TΔSdiss):
12.73
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-140352
Macromolecules
Chain: L
Length: 152 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
Length: 152 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P08709 (Residues: 61-212; Coverage: 34%)
Pfam:
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- EGF-like domain
- Coagulation Factor Xa inhibitory site
- Gamma-carboxyglutamic acid-rich (GLA) domain
- Coagulation factor-like, Gla domain superfamily
- Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
- EGF-like domain
- EGF-like calcium-binding domain
- EGF-like calcium-binding, conserved site
- EGF-type aspartate/asparagine hydroxylation site
Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Trypsin
InterPro:
SCOP: Eukaryotic proteases
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P08709 (Residues: 213-466; Coverage: 57%)
Pfam: Trypsin
InterPro:
- Serine proteases, trypsin domain
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Serine proteases, trypsin family, serine active site
SCOP: Eukaryotic proteases
Chain: T
Length: 218 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam:
InterPro:
SCOP: Fibronectin type III
Length: 218 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P13726 (Residues: 34-251; Coverage: 83%)
Pfam:
InterPro:
- Immunoglobulin-like fold
- Fibronectin type III
- Tissue factor
- Fibronectin type III superfamily
- Tissue factor, conserved site
- Interferon/interleukin receptor domain
SCOP: Fibronectin type III
