EC 3.4.21.73: U-plasminogen activator
Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Systematic name:
-
Alternative Name(s):
- Abbokinase
- Cellular plasminogen activator
- Double-chain urokinase-type plasminogen activator
- Two-chain urokinase-type plasminogen activator
- U-PA
- UPA
- Urinary esterase A
- Urinary plasminogen activator
- Urokinase
- Urokinase plasminogen activator
- Urokinase-type plasminogen activator
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 2 copies in chain <span class='highlight'>B [auth L]</span>. The deposited structure of PDB entry 2fd6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_2_L_CATH_2.60.40.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 2 copies in chain <span class='highlight'>C [auth H]</span>. The deposited structure of PDB entry 2fd6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain C [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_3_H_CATH_2.60.40.10_image-200x200.png)
2.40.20.10
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Plasminogen Kringle 4
Homology:
Plasminogen Kringle 4
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of CATH domain <span class='highlight'>2.40.20.10 (Plasminogen Kringle 4)</span> in <span class='highlight'>Urokinase-type plasminogen activator long chain A</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of CATH domain 2.40.20.10 (Plasminogen Kringle 4) in Urokinase-type plasminogen activator long chain A. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_1_A_CATH_2.40.20.10_image-200x200.png)
SCOP annotations
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 3 copies of SCOP domain <span class='highlight'>57354 (Extracellular domain of cell surface receptors)</span> in <span class='highlight'>Urokinase plasminogen activator surface receptor</span>. Showing 3 copies in chain <span class='highlight'>D [auth U]</span>. The deposited structure of PDB entry 2fd6 contains 3 copies of SCOP domain 57354 (Extracellular domain of cell surface receptors) in Urokinase plasminogen activator surface receptor. Showing 3 copies in chain D [auth U].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_4_U_SCOP_57354_image-200x200.png)
48942
Class:
All beta proteins
Fold:
Immunoglobulin-like beta-sandwich
Superfamily:
Immunoglobulin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>48942 (C1 set domains (antibody constant domain-like))</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_2_L_SCOP_48942_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>48942 (C1 set domains (antibody constant domain-like))</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 1 copy in chain <span class='highlight'>C [auth H]</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain C [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_3_H_SCOP_48942_image-200x200.png)
48727
Class:
All beta proteins
Fold:
Immunoglobulin-like beta-sandwich
Superfamily:
Immunoglobulin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>48727 (V set domains (antibody variable domain-like))</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_2_L_SCOP_48727_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>48727 (V set domains (antibody variable domain-like))</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 1 copy in chain <span class='highlight'>C [auth H]</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig-like domain-containing protein. Showing 1 copy in chain C [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_3_H_SCOP_48727_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>57441 (Kringle modules)</span> in <span class='highlight'>Urokinase-type plasminogen activator long chain A</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 57441 (Kringle modules) in Urokinase-type plasminogen activator long chain A. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_1_A_SCOP_57441_image-200x200.png)
57197
Class:
Small proteins
Fold:
Knottins (small inhibitors, toxins, lectins)
Superfamily:
EGF/Laminin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2fd6</span> contains 1 copy of SCOP domain <span class='highlight'>57197 (EGF-type module)</span> in <span class='highlight'>Urokinase-type plasminogen activator long chain A</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2fd6 contains 1 copy of SCOP domain 57197 (EGF-type module) in Urokinase-type plasminogen activator long chain A. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2fd6_1_A_SCOP_57197_image-200x200.png)