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X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.

X-ray diffraction
1.5Å resolution
PDB entry 2fgv coloured by chain, front view.
PDB entry 2fgv coloured by chain, side view.
PDB entry 2fgv coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: homo dimer
Accessible surface area: 9271.19 Å2
Buried surface area: 5747.63 Å2
Dissociation area: 2,197.13 Å2
Dissociation energy (ΔGdiss): 24.16 kcal/mol
Dissociation entropy (TΔSdiss): 11.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136879

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.81 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03369 (Residues: 491-589; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Protease in PDB entry 2fgv, assembly 1, front view.
Protease in PDB entry 2fgv, assembly 1, side view.
Protease in PDB entry 2fgv, assembly 1, top view.
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