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Enhanced MHC class I binding and immune responses through anchor modification of the non-canonical tumor associated MUC1-8 peptide

X-ray diffraction
2.7Å resolution
PDB entry 2fo4 coloured by chain, front view.
PDB entry 2fo4 coloured by chain, side view.
PDB entry 2fo4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18530.2 Å2
Buried surface area: 6715.06 Å2
Dissociation area: 805.52 Å2
Dissociation energy (ΔGdiss): 6.07 kcal/mol
Dissociation entropy (TΔSdiss): 7.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135107

Macromolecules

Ig-like domain-containing protein
Chain: A
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q3UBW0 (Residues: 22-295; Coverage: 84%)
Gene name: H2-K1
Pfam:
InterPro:
CATH:
SCOP:
Ig-like domain-containing protein in PDB entry 2fo4, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 2fo4, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 2fo4, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 2fo4, assembly 1, front view.
Beta-2-microglobulin in PDB entry 2fo4, assembly 1, side view.
Beta-2-microglobulin in PDB entry 2fo4, assembly 1, top view.
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Mucin-1 subunit alpha
Chain: P
Length: 8 amino acids
Theoretical weight: 903 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P15941 (Residues: 920-927; Coverage: 1%)
Gene names: MUC1, PUM
Mucin-1 subunit alpha in PDB entry 2fo4, assembly 1, front view.
Mucin-1 subunit alpha in PDB entry 2fo4, assembly 1, side view.
Mucin-1 subunit alpha in PDB entry 2fo4, assembly 1, top view.
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