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Human beta tryptase II with inhibitor CRA-28427

X-ray diffraction
2.3Å resolution
PDB entry 2fs9 coloured by chain, front view.
PDB entry 2fs9 coloured by chain, side view.
PDB entry 2fs9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tryptase beta-2 complex
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Multimeric state: homo tetramer
Accessible surface area: 38143.58 Å2
Buried surface area: 10051.59 Å2
Dissociation area: 846.68 Å2
Dissociation energy (ΔGdiss): 3.6 kcal/mol
Dissociation entropy (TΔSdiss): 14.24 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-148879
Complex Portal ID: CPX-3805

Macromolecules

Tryptase beta-2
Chains: A, B, C, D
Length: 245 amino acids
Theoretical weight: 27.49 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P20231 (Residues: 31-275; Coverage: 95%)
Gene names: TPS2, TPSB2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Tryptase beta-2 in PDB entry 2fs9, assembly 1, front view.
Tryptase beta-2 in PDB entry 2fs9, assembly 1, side view.
Tryptase beta-2 in PDB entry 2fs9, assembly 1, top view.
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