› 2ft3

X-ray diffraction
3.4Å resolution

Crystal structure of the biglycan dimer core protein

Released:
DOI: 10.2210/pdb2ft3/pdb
PDB entry 2ft3 coloured by chain, front view.
PDB entry 2ft3 coloured by chain, side view.
PDB entry 2ft3 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans.
Scott PG, Dodd CM, Bergmann EM, Sheehan JK, Bishop PN
J Biol Chem 281 13324-13332 (2006)
PMID: 16547006

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Biglycan Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 332 amino acids
Theoretical weight: 37.4 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P21809 (Residues: 38-369; Coverage: 94%)
Gene name: BGN
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand NAG 6 x NAG
Ligand FLC 6 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 206.511Å b: 119.222Å c: 140.625Å
α: 90° β: 116.61° γ: 90°
R-values:
R R work R free
0.259 0.258 0.291

Quick links

Citations

8 review citations

Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans.
McEwan et al. (2006)
7 more

11 mentions without citation

From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues.
Zappia et al. (2020)
10 more