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Crystal structure of the biglycan dimer core protein

X-ray diffraction
3.4Å resolution
PDB entry 2ft3 coloured by chain, front view.
PDB entry 2ft3 coloured by chain, side view.
PDB entry 2ft3 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Biglycan
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Multimeric state: homo dimer
Accessible surface area: 27950.43 Å2
Buried surface area: 4014.06 Å2
Dissociation area: 1,459.21 Å2
Dissociation energy (ΔGdiss): -8.54 kcal/mol
Dissociation entropy (TΔSdiss): 13.97 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149433
Assembly 2
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Assembly Name: Biglycan
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Multimeric state: homo dimer
Accessible surface area: 28056.74 Å2
Buried surface area: 3895.3 Å2
Dissociation area: 1,490.91 Å2
Dissociation energy (ΔGdiss): -8.72 kcal/mol
Dissociation entropy (TΔSdiss): 13.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149433
Assembly 3
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Assembly Name: Biglycan
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Multimeric state: homo dimer
Accessible surface area: 28167.95 Å2
Buried surface area: 3790.91 Å2
Dissociation area: 1,511.02 Å2
Dissociation energy (ΔGdiss): -8.98 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149433

Macromolecules

Biglycan
Chains: A, B, C, D, E, F
Length: 332 amino acids
Theoretical weight: 37.4 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P21809 (Residues: 38-369; Coverage: 94%)
Gene name: BGN
Pfam:
InterPro:
CATH: Ribonuclease Inhibitor
Biglycan in PDB entry 2ft3, assembly 1, front view.
Biglycan in PDB entry 2ft3, assembly 1, side view.
Biglycan in PDB entry 2ft3, assembly 1, top view.
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