Assemblies
Assembly Name:
Insulin complex and Insulin-degrading enzyme
Multimeric state:
hetero dimer
Accessible surface area:
38391.56 Å2
Buried surface area:
2381.58 Å2
Dissociation area:
1,000.02
Å2
Dissociation energy (ΔGdiss):
27.57
kcal/mol
Dissociation entropy (TΔSdiss):
8.52
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-134207
Assembly Name:
Insulin complex and Insulin-degrading enzyme
Multimeric state:
hetero dimer
Accessible surface area:
38190.93 Å2
Buried surface area:
2422.85 Å2
Dissociation area:
1,020.61
Å2
Dissociation energy (ΔGdiss):
24.58
kcal/mol
Dissociation entropy (TΔSdiss):
8.38
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-134207
Macromolecules
Chains: A, B
Length: 990 amino acids
Theoretical weight: 114.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam:
Length: 990 amino acids
Theoretical weight: 114.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P14735 (Residues: 42-1019; Coverage: 96%)
Pfam:
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
- Middle or third domain of peptidase_M16
- Metalloenzyme, LuxS/M16 peptidase-like
- Peptidase M16, N-terminal
- Peptidase M16, C-terminal
- Peptidase M16, middle/third domain
Chains: C, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Pfam: Insulin/IGF/Relaxin family
InterPro:
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Pfam: Insulin/IGF/Relaxin family
InterPro:
