Assemblies
Assembly Name:
Large T antigen and Cellular tumor antigen p53
Multimeric state:
hetero dodecamer
Accessible surface area:
135921.04 Å2
Buried surface area:
36517.71 Å2
Dissociation area:
18,117.64
Å2
Dissociation energy (ΔGdiss):
68.48
kcal/mol
Dissociation entropy (TΔSdiss):
155.55
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-136541
Assembly Name:
Large T antigen and Cellular tumor antigen p53
Multimeric state:
hetero dodecamer
Accessible surface area:
135640.16 Å2
Buried surface area:
35843.06 Å2
Dissociation area:
17,880.33
Å2
Dissociation energy (ΔGdiss):
63.45
kcal/mol
Dissociation entropy (TΔSdiss):
155.11
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-136541
Macromolecules
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 370 amino acids
Theoretical weight: 42.65 KDa
Source organism: Macaca mulatta polyomavirus 1
Expression system: Escherichia coli
UniProt:
InterPro:
Length: 370 amino acids
Theoretical weight: 42.65 KDa
Source organism: Macaca mulatta polyomavirus 1
Expression system: Escherichia coli
UniProt:
- Canonical:
P03070 (Residues: 260-627; Coverage: 52%)
InterPro:
- Zinc finger, large T-antigen D1 domain superfamily
- Large T antigen, polyomavirus, C-terminal
- Zinc finger, large T-antigen D1-type
- P-loop containing nucleoside triphosphate hydrolase
- Helicase, superfamily 3, DNA virus
- Zinc finger, large T-antigen D1 domain
- Large T antigen, SV40, domain 3
- P-loop containing nucleotide triphosphate hydrolases
Chains: M, N, O, P, Q, R, S, T, U, V, W, X
Length: 203 amino acids
Theoretical weight: 22.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: P53 DNA-binding domain
InterPro:
SCOP: p53 DNA-binding domain-like
Length: 203 amino acids
Theoretical weight: 22.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P04637 (Residues: 92-292; Coverage: 51%)
Pfam: P53 DNA-binding domain
InterPro:
- p53 tumour suppressor family
- p53/RUNT-type transcription factor, DNA-binding domain superfamily
- p53-like transcription factor, DNA-binding domain superfamily
- p53, DNA-binding domain
SCOP: p53 DNA-binding domain-like
