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STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION

X-ray diffraction
2.5Å resolution
PDB entry 2hap coloured by chain, front view.
PDB entry 2hap coloured by chain, side view.
PDB entry 2hap coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heme-responsive zinc finger transcription factor HAP1 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 15461.48 Å2
Buried surface area: 7733.22 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115333

Macromolecules

Heme-responsive zinc finger transcription factor HAP1
Chains: C, D
Length: 81 amino acids
Theoretical weight: 9.7 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CS82 (Residues: 55-135; Coverage: 6%)
Gene names: CYP1, HAP1
Pfam: Fungal Zn(2)-Cys(6) binuclear cluster domain
InterPro:
CATH:
SCOP:
Heme-responsive zinc finger transcription factor HAP1 in PDB entry 2hap, assembly 1, front view.
Heme-responsive zinc finger transcription factor HAP1 in PDB entry 2hap, assembly 1, side view.
Heme-responsive zinc finger transcription factor HAP1 in PDB entry 2hap, assembly 1, top view.
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DNA chain A
Name: DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3')
Representative chains: A
Source organism: Saccharomyces cerevisiae [4932]
Expression system: Not provided
Length: 20 nucleotides
Theoretical weight: 6.1 KDa
DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3') in PDB entry 2hap, assembly 1, front view.
DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3') in PDB entry 2hap, assembly 1, side view.
DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3') in PDB entry 2hap, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3')
Representative chains: B
Source organism: Saccharomyces cerevisiae [4932]
Expression system: Not provided
Length: 20 nucleotides
Theoretical weight: 6.17 KDa
DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3') in PDB entry 2hap, assembly 1, front view.
DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3') in PDB entry 2hap, assembly 1, side view.
DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3') in PDB entry 2hap, assembly 1, top view.
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