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Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain

Source organism: Saccharomyces cerevisiae
Biochemical function: 3'-5' exonuclease activity
Biological process: cellular metabolic process
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00570
Domain description: HRDC domain
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of Pfam domain PF00570 (HRDC domain) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.

PF01612
Domain description: 3'-5' exonuclease
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of Pfam domain PF01612 (3'-5' exonuclease) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002121
Domain description: HRDC domain
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR002562
Domain description: 3'-5' exonuclease domain
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR044876
Domain description: HRDC domain superfamily
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR010997
Domain description: HRDC-like superfamily
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR045092
Domain description: Exosome complex exonuclease Rrp6-like
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Exosome complex exonuclease RRP6
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Exosome complex exonuclease RRP6

Structure domains

CATH CATH domains
1.10.150.80
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: HRDC domain
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of CATH domain 1.10.150.80 (DNA polymerase; domain 1) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.
SCOP SCOP annotations
140646
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: HRDC-like
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of SCOP domain 140646 (EXOSC10 HRDC domain-like) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.
53118
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Ribonuclease H-like
Occurring in:
  1. Exosome complex exonuclease RRP6
The deposited structure of PDB entry 2hbj contains 1 copy of SCOP domain 53118 (DnaQ-like 3'-5' exonuclease) in Exosome complex exonuclease RRP6. Showing 1 copy in chain A.

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