Function and Biology

Crystal structure of the complex between OX40L and OX40

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor activity
Biological process: inflammatory response
Cellular component: membrane

Sequence family

Pfam Protein family (Pfam)
PF00020
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
The deposited structure of PDB entry 2hev contains 3 copies of Pfam domain PF00020 (TNFR/NGFR cysteine-rich region) in Tumor necrosis factor receptor superfamily member 4. Showing 3 copies in chain B [auth R].

InterPro InterPro annotations
IPR001368
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4
IPR034022
Domain description: Tumour necrosis factor receptor 4, N-terminal
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
IPR020445
Domain description: Tumour necrosis factor receptor 4
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4
IPR042338
Domain description: Tumor necrosis factor ligand superfamily member 4
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4

Structure domains

CATH CATH domains
2.10.50.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Tumor Necrosis Factor Receptor, subunit A; domain 2
Homology: Tumor Necrosis Factor Receptor, subunit A, domain 2
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
The deposited structure of PDB entry 2hev contains 2 copies of CATH domain 2.10.50.10 (Tumor Necrosis Factor Receptor, subunit A; domain 2) in Tumor necrosis factor receptor superfamily member 4. Showing 2 copies in chain B [auth R].
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4
The deposited structure of PDB entry 2hev contains 1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor ligand superfamily member 4. Showing 1 copy in chain A [auth F].
SCOP SCOP annotations
57587
Class: Small proteins
Fold: TNF receptor-like
Superfamily: TNF receptor-like
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 4
The deposited structure of PDB entry 2hev contains 3 copies of SCOP domain 57587 (TNF receptor-like) in Tumor necrosis factor receptor superfamily member 4. Showing 3 copies in chain B [auth R].
49843
Class: All beta proteins
Fold: TNF-like
Superfamily: TNF-like
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 4
The deposited structure of PDB entry 2hev contains 1 copy of SCOP domain 49843 (TNF-like) in Tumor necrosis factor ligand superfamily member 4. Showing 1 copy in chain A [auth F].