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Bifidobacterium longum bile salt hydrolase

X-ray diffraction
2.5Å resolution
PDB entry 2hez coloured by chain, front view.
PDB entry 2hez coloured by chain, side view.
PDB entry 2hez coloured by chain, top view.
Source organism: Bifidobacterium longum
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bile salt hydrolase/transferase
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Multimeric state: homo tetramer
Accessible surface area: 44568.31 Å2
Buried surface area: 15771.82 Å2
Dissociation area: 3,786.7 Å2
Dissociation energy (ΔGdiss): 71.09 kcal/mol
Dissociation entropy (TΔSdiss): 15.45 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-191912
Homo tetrameric assembly 1 of PDB entry 2hez coloured by chemically distinct molecules, front view.
Homo tetrameric assembly 1 of PDB entry 2hez coloured by chemically distinct molecules, side view.
Homo tetrameric assembly 1 of PDB entry 2hez coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 4
Symmetry : D2
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3DComplex & QSbio predictionx
No. subunits : 4
Symmetry : D2
Evidence : Interface geometry is similar to that of 2bjf_1 (36% id)

Macromolecules

Bile salt hydrolase/transferase
Chains: A, B
Length: 316 amino acids
Theoretical weight: 35.1 KDa
Source organism: Bifidobacterium longum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9KK62 (Residues: 2-317; Coverage: 100%)
Gene name: bsh
Pfam: Linear amide C-N hydrolases, choloylglycine hydrolase family
InterPro:
CATH: Penicillin V Acylase; Chain A
Conjugated bile acid hydrolase in PDB entry 2hez, assembly 1, front view.
Conjugated bile acid hydrolase in PDB entry 2hez, assembly 1, side view.
Conjugated bile acid hydrolase in PDB entry 2hez, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9KK62  
131620406080100120140160180200220240260280300
 
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UniProt
Q9KK62
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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