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Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue.

Blicher T, Kastrup JS, Pedersen LØ, Buus S, Gajhede M
Acta Crystallogr Sect F Struct Biol Cryst Commun 62 1179-84 (2006)
Cited: 10 times
EuropePMC logo PMID: 17142892

Abstract

A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).

Articles - 2hn7 mentioned but not cited (8)

  1. Epitope based vaccine prediction for SARS-COV-2 by deploying immuno-informatics approach. Joshi A, Joshi BC, Mannan MA, Kaushik V. Inform Med Unlocked 19 100338 (2020)
  2. Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy? Lundegaard C, Lund O, Nielsen M. Expert Rev Vaccines 11 43-54 (2012)
  3. Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, Parham P. J Immunol 186 1575-1588 (2011)
  4. Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01. Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA. Nat Commun 10 893 (2019)
  5. Identification of SARS-CoV-2 CTL epitopes for development of a multivalent subunit vaccine for COVID-19. Rencilin CF, Rosy JC, Mohan M, Coico R, Sundar K. Infect Genet Evol 89 104712 (2021)
  6. Immunogenicity and antigenicity based T-cell and B-cell epitopes identification from conserved regions of 10664 SARS-CoV-2 genomes. Ghosh N, Sharma N, Saha I. Infect Genet Evol 92 104823 (2021)
  7. Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine Design. Mei X, Gu P, Shen C, Lin X, Li J. Front Immunol 13 847617 (2022)
  8. Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue. Blicher T, Kastrup JS, Pedersen LØ, Buus S, Gajhede M. Acta Crystallogr Sect F Struct Biol Cryst Commun 62 1179-1184 (2006)


Reviews citing this publication (1)

  1. Structural and functional distinctiveness of HLA-A2 allelic variants. Chen KY, Liu J, Ren EC. Immunol Res 53 182-190 (2012)

Articles citing this publication (1)

  1. Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides. Choo JA, Thong SY, Yap J, van Esch WJ, Raida M, Meijers R, Lescar J, Verhelst SH, Grotenbreg GM. Angew Chem Int Ed Engl 53 13390-13394 (2014)


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