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Binding of inhibitors by Acylaminoacyl-peptidase

X-ray diffraction
2Å resolution
PDB entry 2hu5 coloured by chain, front view.
PDB entry 2hu5 coloured by chain, side view.
PDB entry 2hu5 coloured by chain, top view.
Source organism: Aeropyrum pernix
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acylamino-acid-releasing enzyme
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Multimeric state: homo dimer
Accessible surface area: 37509.05 Å2
Buried surface area: 3548.3 Å2
Dissociation area: 1,178.88 Å2
Dissociation energy (ΔGdiss): 2.81 kcal/mol
Dissociation entropy (TΔSdiss): 14.74 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195456

Macromolecules

Acylamino-acid-releasing enzyme
Chains: A, B
Length: 582 amino acids
Theoretical weight: 63.11 KDa
Source organism: Aeropyrum pernix
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9YBQ2 (Residues: 1-582; Coverage: 100%)
Gene name: APE_1547.1
Pfam:
InterPro:
CATH:
SCOP:
Acylamino-acid-releasing enzyme in PDB entry 2hu5, assembly 1, front view.
Acylamino-acid-releasing enzyme in PDB entry 2hu5, assembly 1, side view.
Acylamino-acid-releasing enzyme in PDB entry 2hu5, assembly 1, top view.
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