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Structure of the Mediator head subcomplex Med18/20

X-ray diffraction
2.4Å resolution
PDB entry 2hzm coloured by chain, front view.
PDB entry 2hzm coloured by chain, side view.
PDB entry 2hzm coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mediator of RNA polymerase II transcription
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Multimeric state: hetero dimer
Accessible surface area: 20418.19 Å2
Buried surface area: 3692.03 Å2
Dissociation area: 1,731.31 Å2
Dissociation energy (ΔGdiss): 22.78 kcal/mol
Dissociation entropy (TΔSdiss): 12.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152374
Assembly 2
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Assembly Name: Mediator of RNA polymerase II transcription
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Multimeric state: hetero dimer
Accessible surface area: 20024.15 Å2
Buried surface area: 3160.9 Å2
Dissociation area: 1,580.45 Å2
Dissociation energy (ΔGdiss): 19.74 kcal/mol
Dissociation entropy (TΔSdiss): 12.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152374
Assembly 3
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Assembly Name: Mediator of RNA polymerase II transcription
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Multimeric state: hetero dimer
Accessible surface area: 20201.05 Å2
Buried surface area: 3203.74 Å2
Dissociation area: 1,601.87 Å2
Dissociation energy (ΔGdiss): 19.07 kcal/mol
Dissociation entropy (TΔSdiss): 12.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152374
Assembly 4
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Assembly Name: Mediator of RNA polymerase II transcription
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Multimeric state: hetero dimer
Accessible surface area: 19716.98 Å2
Buried surface area: 3199.37 Å2
Dissociation area: 1,599.68 Å2
Dissociation energy (ΔGdiss): 19.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152374

Macromolecules

Mediator of RNA polymerase II transcription subunit 20
Chains: A, C, E, G
Length: 212 amino acids
Theoretical weight: 23.08 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P34162 (Residues: 1-210; Coverage: 100%)
Gene names: HRS2, MED20, SRB2, YHR041C
Pfam: TATA-binding related factor (TRF) of subunit 20 of Mediator complex
InterPro:
CATH:
Mediator of RNA polymerase II transcription subunit 20 in PDB entry 2hzm, assembly 1, front view.
Mediator of RNA polymerase II transcription subunit 20 in PDB entry 2hzm, assembly 1, side view.
Mediator of RNA polymerase II transcription subunit 20 in PDB entry 2hzm, assembly 1, top view.
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Mediator of RNA polymerase II transcription subunit 18
Chains: B, D, F, H
Length: 317 amino acids
Theoretical weight: 35.5 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P32585 (Residues: 2-307; Coverage: 100%)
Gene names: MED18, SRB5, YGR104C
Pfam: Med18 protein
InterPro: Mediator complex, subunit Med18
CATH: Hypothetical Protein Pfu-838710-001
Mediator of RNA polymerase II transcription subunit 18 in PDB entry 2hzm, assembly 1, front view.
Mediator of RNA polymerase II transcription subunit 18 in PDB entry 2hzm, assembly 1, side view.
Mediator of RNA polymerase II transcription subunit 18 in PDB entry 2hzm, assembly 1, top view.
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