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T. Brucei farnesyl diphosphate synthase complexed with bisphosphonate

X-ray diffraction
2.28Å resolution
PDB entry 2i19 coloured by chain, front view.
PDB entry 2i19 coloured by chain, side view.
PDB entry 2i19 coloured by chain, top view.
Source organism: Trypanosoma brucei
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Farnesyl pyrophosphate synthase
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Multimeric state: homo dimer
Accessible surface area: 28493.01 Å2
Buried surface area: 8270.62 Å2
Dissociation area: 3,135.71 Å2
Dissociation energy (ΔGdiss): 33.6 kcal/mol
Dissociation entropy (TΔSdiss): 14.64 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-183122

Macromolecules

Farnesyl pyrophosphate synthase
Chains: A, B
Length: 390 amino acids
Theoretical weight: 44.48 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86C09 (Residues: 1-367; Coverage: 100%)
Pfam: Polyprenyl synthetase
InterPro:
CATH: Farnesyl Diphosphate Synthase
Farnesyl pyrophosphate synthase in PDB entry 2i19, assembly 1, front view.
Farnesyl pyrophosphate synthase in PDB entry 2i19, assembly 1, side view.
Farnesyl pyrophosphate synthase in PDB entry 2i19, assembly 1, top view.
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