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The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site

X-ray diffraction
1.49Å resolution
PDB entry 2imt coloured by chain, front view.
PDB entry 2imt coloured by chain, side view.
PDB entry 2imt coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Bcl-2 homologous antagonist/killer
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Multimeric state: homo dimer
Accessible surface area: 14966.92 Å2
Buried surface area: 1344.32 Å2
Dissociation area: 647.45 Å2
Dissociation energy (ΔGdiss): 52.19 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172524
Assembly 2 (preferred)
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Assembly Name: Bcl-2 homologous antagonist/killer
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Multimeric state: monomeric
Accessible surface area: 8060.06 Å2
Buried surface area: 91.95 Å2
Dissociation area: 45.98 Å2
Dissociation energy (ΔGdiss): 27.45 kcal/mol
Dissociation entropy (TΔSdiss): -0.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172520

Macromolecules

Bcl-2 homologous antagonist/killer
Chain: A
Length: 171 amino acids
Theoretical weight: 19.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16611 (Residues: 16-186; Coverage: 81%)
Gene names: BAK, BAK1, BCL2L7, CDN1
Pfam: Apoptosis regulator proteins, Bcl-2 family
InterPro:
CATH: Blc2-like
Bcl-2 homologous antagonist/killer in PDB entry 2imt, assembly 2, front view.
Bcl-2 homologous antagonist/killer in PDB entry 2imt, assembly 2, side view.
Bcl-2 homologous antagonist/killer in PDB entry 2imt, assembly 2, top view.
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