EC 2.7.7.6: DNA-directed RNA polymerase
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
- C RNA formation factors
- C ribonucleic acid formation factors
- DNA-dependent RNA nucleotidyltransferase
- DNA-dependent RNA polymerase
- DNA-dependent ribonucleate nucleotidyltransferase
- Deoxyribonucleic acid-dependent ribonucleic acid polymerase
- RNA nucleotidyltransferase
- RNA nucleotidyltransferase (DNA-directed)
- RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA transcriptase
- Ribonucleate nucleotidyltransferase
- Ribonucleate polymerase
- Ribonucleic acid nucleotidyltransferase
- Ribonucleic acid polymerase
- Ribonucleic acid transcriptase
- Ribonucleic polymerase
- Ribonucleic transcriptase
- Transcriptase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR005570
Domain description:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Occurring in:
Occurring in:
IPR006591
Domain description:
RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
Occurring in:
IPR012164
Domain description:
DNA-directed RNA polymerase subunit/transcription factor S
Occurring in:
Occurring in:
IPR029040
Domain description:
RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
Occurring in:
IPR039747
Domain description:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Occurring in:
Occurring in:
IPR008193
Domain description:
DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
Occurring in:
IPR009025
Domain description:
DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
Occurring in:
IPR019761
Domain description:
DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Occurring in:
Occurring in:
IPR020708
Domain description:
DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
Occurring in:
IPR001514
Domain description:
DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
Occurring in:
IPR037033
Domain description:
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
Occurring in:
IPR007120
Domain description:
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
Occurring in:
Structure domains
CATH domains
3.30.1360.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Gyrase A; domain 2
Homology:
RNA polymerase, RBP11-like subunit
Occurring in:
2.40.270.10
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homology:
DNA-directed RNA polymerase, subunit 2, domain 6
Occurring in:
2.20.25.10
Class:
Mainly Beta
Architecture:
Single Sheet
Topology:
N-terminal domain of TfIIb
Homology:
N-terminal domain of TfIIb
Occurring in:
2.40.50.140
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology:
Nucleic acid-binding proteins
Occurring in:
1.20.1250.40
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Growth Hormone; Chain: A;
Homology:
Growth Hormone; Chain: A;
Occurring in:
2.40.50.150
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
2.40.40.20
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Barwin-like endoglucanases
Homology:
Barwin-like endoglucanases
Occurring in:
2.20.28.30
Class:
Mainly Beta
Architecture:
Single Sheet
Topology:
Rubrerythrin, domain 2
Homology:
RNA polymerase ii, chain L
Occurring in:
1.10.10.60
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Arc Repressor Mutant, subunit A
Homology:
Homeodomain-like
Occurring in:
3.30.1490.120
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dna Ligase; domain 1
Homology:
RNA polymerase Rpb7-like, N-terminal domain
Occurring in:
3.90.940.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Eukaryotic RPB6 RNA polymerase subunit
Homology:
Eukaryotic RPB6 RNA polymerase subunit
Occurring in:
3.90.940.20
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Eukaryotic RPB6 RNA polymerase subunit
Homology:
RPB5-like RNA polymerase subunit
Occurring in:
3.40.1340.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homology:
RNA polymerase, Rpb5, N-terminal domain
Occurring in:
2.170.120.12
Class:
Mainly Beta
Architecture:
Beta Complex
Topology:
RNA Polymerase Alpha Subunit; Chain A, domain 2
Homology:
DNA-directed RNA polymerase, insert domain
Occurring in:
3.90.1800.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
DCoH-like
Homology:
RNA polymerase alpha subunit dimerisation domain
Occurring in:
3.90.1070.20
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Hypothetical Protein Ta0175; Chain: A, domain 2
Homology:
Hypothetical Protein Ta0175; Chain: A, domain 2
Occurring in:
3.90.1110.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homology:
RNA polymerase Rpb2, domain 2
Occurring in:
3.30.1360.140
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Gyrase A; domain 2
Homology:
Gyrase A; domain 2
Occurring in:
1.10.132.30
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Topoisomerase I; Chain A, domain 4
Homology:
Topoisomerase I; Chain A, domain 4
Occurring in:
1.10.274.100
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Enzyme I; Chain A, domain 2
Homology:
RNA polymerase Rpb1, domain 3
Occurring in:
SCOP annotations
55258
Class:
Alpha and beta proteins (a+b)
Fold:
DCoH-like
Superfamily:
RBP11-like subunits of RNA polymerase
Occurring in:
64576
Class:
Small proteins
Fold:
Rubredoxin-like
Superfamily:
RNA polymerase subunits
Occurring in:
64311
Class:
Alpha and beta proteins (a+b)
Fold:
DCoH-like
Superfamily:
RBP11-like subunits of RNA polymerase
Occurring in:
46925
Class:
All alpha proteins
Fold:
DNA/RNA-binding 3-helical bundle
Superfamily:
RNA polymerase subunit RPB10
Occurring in:
50321
Class:
All beta proteins
Fold:
OB-fold
Superfamily:
Nucleic acid-binding proteins
Occurring in:
50282
Class:
All beta proteins
Fold:
OB-fold
Superfamily:
Nucleic acid-binding proteins
Occurring in:
88799
Class:
Alpha and beta proteins (a+b)
Fold:
Dodecin subunit-like
Superfamily:
N-terminal, heterodimerisation domain of RBP7 (RpoE)
Occurring in:
55294
Class:
All alpha proteins
Fold:
RPB6/omega subunit-like
Superfamily:
RPB6/omega subunit-like
Occurring in:
55288
Class:
Alpha and beta proteins (a+b)
Fold:
RPB5-like RNA polymerase subunit
Superfamily:
RPB5-like RNA polymerase subunit
Occurring in:
53037
Class:
Alpha and beta proteins (a/b)
Fold:
Restriction endonuclease-like
Superfamily:
Eukaryotic RPB5 N-terminal domain
Occurring in:
58182
Class:
Low resolution protein structures
Fold:
RNA polymerase
Superfamily:
RNA polymerase
Occurring in:
56554
Class:
Alpha and beta proteins (a+b)
Fold:
Insert subdomain of RNA polymerase alpha subunit
Superfamily:
Insert subdomain of RNA polymerase alpha subunit
Occurring in:
64485
Class:
Multi-domain proteins (alpha and beta)
Fold:
beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily:
beta and beta-prime subunits of DNA dependent RNA-polymerase
Occurring in:
64490
Class:
Multi-domain proteins (alpha and beta)
Fold:
beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily:
beta and beta-prime subunits of DNA dependent RNA-polymerase
Occurring in: