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Crystal structure of human uridine-cytidine kinase 1

X-ray diffraction
2.5Å resolution
PDB entry 2jeo coloured by chain, front view.
PDB entry 2jeo coloured by chain, side view.
PDB entry 2jeo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Uridine-cytidine kinase 1
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Multimeric state: homo tetramer
Accessible surface area: 39111.31 Å2
Buried surface area: 5953.78 Å2
Dissociation area: 2,976.89 Å2
Dissociation energy (ΔGdiss): 11.09 kcal/mol
Dissociation entropy (TΔSdiss): 39.71 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-190710

Macromolecules

Uridine-cytidine kinase 1
Chain: A
Length: 245 amino acids
Theoretical weight: 28.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HA47 (Residues: 21-243; Coverage: 81%)
Gene names: UCK1, URK1
Pfam: Phosphoribulokinase / Uridine kinase family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Uridine-cytidine kinase 1 in PDB entry 2jeo, assembly 1, front view.
Uridine-cytidine kinase 1 in PDB entry 2jeo, assembly 1, side view.
Uridine-cytidine kinase 1 in PDB entry 2jeo, assembly 1, top view.
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