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V232K, N236D-trichosanthin

X-ray diffraction
2.3Å resolution
PDB entry 2jjr coloured by chain, front view.
PDB entry 2jjr coloured by chain, side view.
PDB entry 2jjr coloured by chain, top view.
Source organism: Trichosanthes kirilowii
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribosome-inactivating protein alpha-trichosanthin
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Multimeric state: monomeric
Accessible surface area: 11366.95 Å2
Buried surface area: 2503.43 Å2
Dissociation area: 165.53 Å2
Dissociation energy (ΔGdiss): -4.49 kcal/mol
Dissociation entropy (TΔSdiss): 1.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140879
Monomeric assembly 1 of PDB entry 2jjr coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 2jjr coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 2jjr coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Ribosome-inactivating protein alpha-trichosanthin
Chain: A
Length: 247 amino acids
Theoretical weight: 27.2 KDa
Source organism: Trichosanthes kirilowii
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P09989 (Residues: 24-270; Coverage: 93%)
Pfam: Ribosome inactivating protein
InterPro:
CATH:
Ribosome-inactivating protein alpha-trichosanthin in PDB entry 2jjr, assembly 1, front view.
Ribosome-inactivating protein alpha-trichosanthin in PDB entry 2jjr, assembly 1, side view.
Ribosome-inactivating protein alpha-trichosanthin in PDB entry 2jjr, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P09989  
124720406080100120140160180200220240
 
100200
UniProt
P09989
Chains
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Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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