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Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA

Solution NMR
PDB entry 2jp9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jp9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jp9 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Wilms tumor protein and DNA
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Multimeric state: hetero trimer
Accessible surface area: 11737.36 Å2
Buried surface area: 5686.31 Å2
Dissociation area: 1,747.12 Å2
Dissociation energy (ΔGdiss): 16.18 kcal/mol
Dissociation entropy (TΔSdiss): 11.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115430

Macromolecules

Wilms tumor protein
Chain: A
Length: 119 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19544 (Residues: 318-438; Coverage: 26%)
  • Best match: P19544-2 (Residues: 301-418)
Gene name: WT1
Pfam: Zinc finger, C2H2 type
InterPro:
CATH: Classic Zinc Finger
Wilms tumor protein in PDB entry 2jp9, assembly 1, front view.
Wilms tumor protein in PDB entry 2jp9, assembly 1, side view.
Wilms tumor protein in PDB entry 2jp9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P19544  
1119102030405060708090100110
 
50100
UniProt
P19544
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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DNA chain B
Name: DNA (5'-D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DGP*DCP*DGP*DC)-3')
Representative chains: B
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 17 nucleotides
Theoretical weight: 5.26 KDa
DNA (5'-D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DGP*DCP*DGP*DC)-3') in PDB entry 2jp9, assembly 1, front view.
DNA (5'-D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DGP*DCP*DGP*DC)-3') in PDB entry 2jp9, assembly 1, side view.
DNA (5'-D(P*DCP*DGP*DCP*DGP*DGP*DGP*DGP*DGP*DCP*DGP*DTP*DCP*DTP*DGP*DCP*DGP*DC)-3') in PDB entry 2jp9, assembly 1, top view.
117246810121416
 
51015
Chains
Chain A (auth B)
Interaction interfaces
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DNA chain C
Name: DNA (5'-D(P*DGP*DCP*DGP*DCP*DAP*DGP*DAP*DCP*DGP*DCP*DCP*DCP*DCP*DCP*DGP*DCP*DG)-3')
Representative chains: C
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 17 nucleotides
Theoretical weight: 5.16 KDa
DNA (5'-D(P*DGP*DCP*DGP*DCP*DAP*DGP*DAP*DCP*DGP*DCP*DCP*DCP*DCP*DCP*DGP*DCP*DG)-3') in PDB entry 2jp9, assembly 1, front view.
DNA (5'-D(P*DGP*DCP*DGP*DCP*DAP*DGP*DAP*DCP*DGP*DCP*DCP*DCP*DCP*DCP*DGP*DCP*DG)-3') in PDB entry 2jp9, assembly 1, side view.
DNA (5'-D(P*DGP*DCP*DGP*DCP*DAP*DGP*DAP*DCP*DGP*DCP*DCP*DCP*DCP*DCP*DGP*DCP*DG)-3') in PDB entry 2jp9, assembly 1, top view.
117246810121416
 
51015
Chains
Chain B (auth C)
Interaction interfaces
Molecule details ›

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