Function and Biology

Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21

Source organism: Homo sapiens
Biochemical function: cytokine binding
Biological process: negative regulation of dendritic cell apoptotic process
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF12109
Domain description: CXCR4 Chemokine receptor N terminal
Occurring in:
  1. C-X-C chemokine receptor type 4
The deposited structure of PDB entry 2k03 contains 2 copies of Pfam domain PF12109 (CXCR4 Chemokine receptor N terminal) in C-X-C chemokine receptor type 4. Showing 1 copy in chain B.

PF00048
Domain description: Small cytokines (intecrine/chemokine), interleukin-8 like
Occurring in:
  1. Stromal cell-derived factor 1
The deposited structure of PDB entry 2k03 contains 2 copies of Pfam domain PF00048 (Small cytokines (intecrine/chemokine), interleukin-8 like) in Stromal cell-derived factor 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001277
Domain description: CXC chemokine receptor 4/atypical chemokine receptor 2
Occurring in:
  1. C-X-C chemokine receptor type 4
IPR001811
Domain description: Chemokine interleukin-8-like domain
Occurring in:
  1. Stromal cell-derived factor 1
IPR022726
Domain description: CXC chemokine receptor 4 N-terminal domain
Occurring in:
  1. C-X-C chemokine receptor type 4
IPR036048
Domain description: Chemokine interleukin-8-like superfamily
Occurring in:
  1. Stromal cell-derived factor 1

Structure domain

CATH CATH domain
2.40.50.40
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Stromal cell-derived factor 1
The deposited structure of PDB entry 2k03 contains 2 copies of CATH domain 2.40.50.40 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Stromal cell-derived factor 1. Showing 1 copy in chain A.