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Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21

Solution NMR
PDB entry 2k03 coloured by chain, ensemble of 20 models, front view.
PDB entry 2k03 coloured by chain, ensemble of 20 models, side view.
PDB entry 2k03 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-X-C chemokine receptor type 4 and Stromal cell-derived factor 1
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Multimeric state: hetero tetramer
Accessible surface area: 12342.81 Å2
Buried surface area: 8659.28 Å2
Dissociation area: 1,762.45 Å2
Dissociation energy (ΔGdiss): 8.13 kcal/mol
Dissociation entropy (TΔSdiss): 11.94 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155707

Macromolecules

Stromal cell-derived factor 1
Chains: A, C
Length: 70 amino acids
Theoretical weight: 8.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48061 (Residues: 22-89; Coverage: 94%)
  • Best match: P48061-7 (Residues: 22-38)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Pfam: Small cytokines (intecrine/chemokine), interleukin-8 like
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Stromal cell-derived factor 1 in PDB entry 2k03, assembly 1, front view.
Stromal cell-derived factor 1 in PDB entry 2k03, assembly 1, side view.
Stromal cell-derived factor 1 in PDB entry 2k03, assembly 1, top view.
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C-X-C chemokine receptor type 4
Chains: B, D
Length: 40 amino acids
Theoretical weight: 4.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61073 (Residues: 1-38; Coverage: 11%)
Gene name: CXCR4
Pfam: CXCR4 Chemokine receptor N terminal
InterPro:
C-X-C chemokine receptor type 4 in PDB entry 2k03, assembly 1, front view.
C-X-C chemokine receptor type 4 in PDB entry 2k03, assembly 1, side view.
C-X-C chemokine receptor type 4 in PDB entry 2k03, assembly 1, top view.
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