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Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)

Solution NMR
PDB entry 2k8r coloured by chain, ensemble of 20 models, front view.
PDB entry 2k8r coloured by chain, ensemble of 20 models, side view.
PDB entry 2k8r coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor 1
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Multimeric state: monomeric
Accessible surface area: 7505.67 Å2
Buried surface area: 608.88 Å2
Dissociation area: 304.44 Å2
Dissociation energy (ΔGdiss): 8.13 kcal/mol
Dissociation entropy (TΔSdiss): 5.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138603

Macromolecules

Fibroblast growth factor 1
Chain: A
Length: 133 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 23-155; Coverage: 86%)
Gene names: FGF1, FGFA
Pfam: Fibroblast growth factor
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor 1 in PDB entry 2k8r, assembly 1, front view.
Fibroblast growth factor 1 in PDB entry 2k8r, assembly 1, side view.
Fibroblast growth factor 1 in PDB entry 2k8r, assembly 1, top view.
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