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Solution NMR

Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7

Released:
DOI: 10.2210/pdb2krd/pdb
PDB entry 2krd coloured by chain, ensemble of 20 models, front view.
PDB entry 2krd coloured by chain, ensemble of 20 models, side view.
PDB entry 2krd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction.
Oleszczuk M, Robertson IM, Li MX, Sykes BD
J Mol Cell Cardiol 48 925-33 (2010)
PMID: 20116385

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148574 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Troponin C, slow skeletal and cardiac muscles Chain: C
Molecule details ›
Chain: C
Length: 89 amino acids
Theoretical weight: 10.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Troponin I, cardiac muscle Chain: I
Molecule details ›
Chain: I
Length: 17 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P19429 (Residues: 148-164; Coverage: 8%)
Gene names: TNNC1, TNNI3

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand WW7 1 x WW7
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Targeting the sarcomere to correct muscle function.
Hwang et al. (2015)
1 more

9 mentions without citation

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.
Li et al. (2015)
8 more