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Solution NMR Structure of the Ras-binding domain of Serine/threonine-protein kinase B-raf from Homo sapiens, Northeast Structural Genomics Consortium Target HR4694F

Solution NMR
PDB entry 2l05 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l05 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l05 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase B-raf
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Multimeric state: monomeric
Accessible surface area: 6546.27 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147194

Macromolecules

Serine/threonine-protein kinase B-raf
Chain: A
Length: 95 amino acids
Theoretical weight: 10.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15056 (Residues: 149-232; Coverage: 11%)
Gene names: BRAF, BRAF1, RAFB1
Pfam: Raf-like Ras-binding domain
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Serine/threonine-protein kinase B-raf in PDB entry 2l05, assembly 1, front view.
Serine/threonine-protein kinase B-raf in PDB entry 2l05, assembly 1, side view.
Serine/threonine-protein kinase B-raf in PDB entry 2l05, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P15056  
195102030405060708090
 
50MGHHHHHHSHMPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPL
UniProt
P15056
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
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