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Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5

Solution NMR
PDB entry 2l53 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l53 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l53 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sodium channel protein type 5 subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 11677.96 Å2
Buried surface area: 1878.71 Å2
Dissociation area: 939.36 Å2
Dissociation energy (ΔGdiss): 7.37 kcal/mol
Dissociation entropy (TΔSdiss): 9.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162863

Macromolecules

Calmodulin
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
Calmodulin in PDB entry 2l53, assembly 1, front view.
Calmodulin in PDB entry 2l53, assembly 1, side view.
Calmodulin in PDB entry 2l53, assembly 1, top view.
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Sodium channel protein type 5 subunit alpha
Chain: B
Length: 31 amino acids
Theoretical weight: 3.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14524 (Residues: 1901-1927; Coverage: 1%)
Gene name: SCN5A
InterPro: IQ motif, EF-hand binding site
Sodium channel protein type 5 subunit alpha in PDB entry 2l53, assembly 1, front view.
Sodium channel protein type 5 subunit alpha in PDB entry 2l53, assembly 1, side view.
Sodium channel protein type 5 subunit alpha in PDB entry 2l53, assembly 1, top view.
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