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Structure of the transmembrane domain of human nicastrin in DPC micelles

Solution NMR
PDB entry 2n7r coloured by chain, ensemble of 20 models, front view.
PDB entry 2n7r coloured by chain, ensemble of 20 models, side view.
PDB entry 2n7r coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nicastrin
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Multimeric state: monomeric
Accessible surface area: 4770.53 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187681

Macromolecules

Nicastrin
Chain: A
Length: 54 amino acids
Theoretical weight: 5.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92542 (Residues: 664-709; Coverage: 7%)
Gene names: KIAA0253, NCSTN, UNQ1874/PRO4317
Nicastrin in PDB entry 2n7r, assembly 1, front view.
Nicastrin in PDB entry 2n7r, assembly 1, side view.
Nicastrin in PDB entry 2n7r, assembly 1, top view.
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