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Crystal structure of PurO/AICAR from Methanothermobacter thermoautotrophicus

X-ray diffraction
2.6Å resolution
PDB entry 2ntl coloured by chain, front view.
PDB entry 2ntl coloured by chain, side view.
PDB entry 2ntl coloured by chain, top view.
Source organism: Methanothermobacter thermautotrophicus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IMP cyclohydrolase
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Multimeric state: homo tetramer
Accessible surface area: 28529.82 Å2
Buried surface area: 9023.85 Å2
Dissociation area: 3,262.71 Å2
Dissociation energy (ΔGdiss): 14.71 kcal/mol
Dissociation entropy (TΔSdiss): 38.82 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-127874

Macromolecules

IMP cyclohydrolase
Chains: A, B, C, D
Length: 222 amino acids
Theoretical weight: 24.03 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O27099 (Residues: 1-202; Coverage: 100%)
Gene names: MTH_1020, purO
Pfam: IMP cyclohydrolase-like protein
InterPro:
CATH: Inosine monophosphate cyclohydrolase-like
SCOP: Archaeal IMP cyclohydrolase PurO
IMP cyclohydrolase in PDB entry 2ntl, assembly 1, front view.
IMP cyclohydrolase in PDB entry 2ntl, assembly 1, side view.
IMP cyclohydrolase in PDB entry 2ntl, assembly 1, top view.
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