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Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer

X-ray diffraction
2.8Å resolution
PDB entry 2o61 coloured by chain, front view.
PDB entry 2o61 coloured by chain, side view.
PDB entry 2o61 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear factor NF-kappa-B p50 subunit and Interferon regulatory factor 3, Interferon regulatory factor 7, Transcription factor p65 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 49798.26 Å2
Buried surface area: 12351.87 Å2
Dissociation area: 1,625.32 Å2
Dissociation energy (ΔGdiss): 20.07 kcal/mol
Dissociation entropy (TΔSdiss): 14.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115708

Macromolecules

Interferon regulatory factor 3; Interferon regulatory factor 7; Transcription factor p65
Chain: A
Length: 540 amino acids
Theoretical weight: 61.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04206 (Residues: 20-291; Coverage: 49%)
  • Canonical: Q92985 (Residues: 8-125; Coverage: 24%)
  • Canonical: Q14653 (Residues: 9-111; Coverage: 24%)
    • nullnullnull
Gene names: IRF3, IRF7, NFKB3, RELA
Pfam:
InterPro:
CATH:
Interferon regulatory factor 3 in PDB entry 2o61, assembly 1, front view.
Interferon regulatory factor 3 in PDB entry 2o61, assembly 1, side view.
Interferon regulatory factor 3 in PDB entry 2o61, assembly 1, top view.
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Nuclear factor NF-kappa-B p50 subunit
Chain: B
Length: 314 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19838 (Residues: 40-352; Coverage: 32%)
Gene name: NFKB1
Pfam:
InterPro:
CATH:
SCOP:
Nuclear factor NF-kappa-B p50 subunit in PDB entry 2o61, assembly 1, front view.
Nuclear factor NF-kappa-B p50 subunit in PDB entry 2o61, assembly 1, side view.
Nuclear factor NF-kappa-B p50 subunit in PDB entry 2o61, assembly 1, top view.
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DNA chain E
Name: 36-MER
Representative chains: E
Length: 36 nucleotides
Theoretical weight: 11.27 KDa
36-MER in PDB entry 2o61, assembly 1, front view.
36-MER in PDB entry 2o61, assembly 1, side view.
36-MER in PDB entry 2o61, assembly 1, top view.
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DNA chain F
Name: 34-MER
Representative chains: F
Length: 34 nucleotides
Theoretical weight: 10.26 KDa
34-MER in PDB entry 2o61, assembly 1, front view.
34-MER in PDB entry 2o61, assembly 1, side view.
34-MER in PDB entry 2o61, assembly 1, top view.
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