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The second SH3 domain from Ponsin in complex with the paxillin proline rich region

X-ray diffraction
1.63Å resolution
PDB entry 2o9v coloured by chain, front view.
PDB entry 2o9v coloured by chain, side view.
PDB entry 2o9v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sorbin and SH3 domain-containing protein 1 and Paxillin
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Multimeric state: hetero dimer
Accessible surface area: 5158.95 Å2
Buried surface area: 765.38 Å2
Dissociation area: 382.69 Å2
Dissociation energy (ΔGdiss): 1.19 kcal/mol
Dissociation entropy (TΔSdiss): 6.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155832

Macromolecules

Sorbin and SH3 domain-containing protein 1
Chain: A
Length: 67 amino acids
Theoretical weight: 7.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BX66 (Residues: 870-930; Coverage: 5%)
Gene names: KIAA0894, KIAA1296, SH3D5, SORBS1
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
Sorbin and SH3 domain-containing protein 1 in PDB entry 2o9v, assembly 1, front view.
Sorbin and SH3 domain-containing protein 1 in PDB entry 2o9v, assembly 1, side view.
Sorbin and SH3 domain-containing protein 1 in PDB entry 2o9v, assembly 1, top view.
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Paxillin
Chain: B
Length: 10 amino acids
Theoretical weight: 983 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49023 (Residues: 45-54; Coverage: 2%)
Gene name: PXN
Paxillin in PDB entry 2o9v, assembly 1, front view.
Paxillin in PDB entry 2o9v, assembly 1, side view.
Paxillin in PDB entry 2o9v, assembly 1, top view.
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