› 2oid

X-ray diffraction
2.3Å resolution

Crystal structure of IRAK4 kinase domain complexed with AMPPNP

Released:
DOI: 10.2210/pdb2oid/pdb
PDB entry 2oid coloured by chain, front view.
PDB entry 2oid coloured by chain, side view.
PDB entry 2oid coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations.
Kuglstatter A, Villaseñor AG, Shaw D, Lee SW, Tsing S, Niu L, Song KW, Barnett JW, Browner MF
J Immunol 178 2641-5 (2007)
PMID: 17312103

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 33.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 160-460; Coverage: 65%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 4 x ANP
2 modified residues:
Ligand TPO 8 x TPO
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 147.116Å b: 138.973Å c: 89.198Å
α: 90° β: 126.43° γ: 90°
R-values:
R R work R free
0.244 0.241 0.295
Expression system: unidentified baculovirus

Quick links

Citations

8 review citations

IRAK1: a critical signaling mediator of innate immunity.
Gottipati et al. (2008)
7 more

10 mentions without citation

IRAK-4 inhibitors for inflammation.
Wang et al. (2009)
9 more