› › Structure analysis

Crystal structure of IRAK4 kinase domain complexed with AMPPNP

X-ray diffraction
2.3Å resolution
PDB entry 2oid coloured by chain, front view.
PDB entry 2oid coloured by chain, side view.
PDB entry 2oid coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13031.6 Å2
Buried surface area: 859.54 Å2
Dissociation area: 429.77 Å2
Dissociation energy (ΔGdiss): -1.35 kcal/mol
Dissociation entropy (TΔSdiss): 5.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 2
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13274.14 Å2
Buried surface area: 823.37 Å2
Dissociation area: 411.68 Å2
Dissociation energy (ΔGdiss): -0.39 kcal/mol
Dissociation entropy (TΔSdiss): 5.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 3
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13240.64 Å2
Buried surface area: 794.48 Å2
Dissociation area: 397.24 Å2
Dissociation energy (ΔGdiss): -1.47 kcal/mol
Dissociation entropy (TΔSdiss): 5.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 4
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13426.47 Å2
Buried surface area: 875.01 Å2
Dissociation area: 437.5 Å2
Dissociation energy (ΔGdiss): -1.77 kcal/mol
Dissociation entropy (TΔSdiss): 5.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669

Macromolecules

Interleukin-1 receptor-associated kinase 4
Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 33.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 160-460; Coverage: 65%)
Gene name: IRAK4
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oid, assembly 1, front view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oid, assembly 1, side view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2oid, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links