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Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor

X-ray diffraction
2.4Å resolution
PDB entry 2oph coloured by chain, front view.
PDB entry 2oph coloured by chain, side view.
PDB entry 2oph coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dipeptidyl peptidase 4
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Multimeric state: homo dimer
Accessible surface area: 60190.85 Å2
Buried surface area: 12227.19 Å2
Dissociation area: 2,194.82 Å2
Dissociation energy (ΔGdiss): 20.63 kcal/mol
Dissociation entropy (TΔSdiss): 15.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151015

Macromolecules

Dipeptidyl peptidase 4
Chains: A, B
Length: 728 amino acids
Theoretical weight: 84.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 39-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Pfam:
InterPro:
CATH:
SCOP:
Dipeptidyl peptidase 4 in PDB entry 2oph, assembly 1, front view.
Dipeptidyl peptidase 4 in PDB entry 2oph, assembly 1, side view.
Dipeptidyl peptidase 4 in PDB entry 2oph, assembly 1, top view.
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