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crystal structure of PDE10A2 mutant D674A

X-ray diffraction
1.45Å resolution
PDB entry 2ous coloured by chain, front view.
PDB entry 2ous coloured by chain, side view.
PDB entry 2ous coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: monomeric
Accessible surface area: 14984.45 Å2
Buried surface area: 120.67 Å2
Dissociation area: 60.33 Å2
Dissociation energy (ΔGdiss): 10.34 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195088
Assembly 2
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: monomeric
Accessible surface area: 15483.35 Å2
Buried surface area: 118.67 Å2
Dissociation area: 59.33 Å2
Dissociation energy (ΔGdiss): 10.26 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195088

Macromolecules

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Chains: A, B
Length: 331 amino acids
Theoretical weight: 38.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y233 (Residues: 715-1042; Coverage: 31%)
Gene name: PDE10A
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ous, assembly 1, front view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ous, assembly 1, side view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ous, assembly 1, top view.
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