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Crystal structure of the catalytic domain of rat phosphodiesterase 10A

X-ray diffraction
1.8Å resolution
PDB entry 2ovy coloured by chain, front view.
PDB entry 2ovy coloured by chain, side view.
PDB entry 2ovy coloured by chain, top view.
Source organism: Rattus norvegicus
Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: monomeric
Accessible surface area: 14150.65 Å2
Buried surface area: 1138.89 Å2
Dissociation area: 45.77 Å2
Dissociation energy (ΔGdiss): 4.42 kcal/mol
Dissociation entropy (TΔSdiss): 0.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193052
Monomeric assembly 1 of PDB entry 2ovy coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 2ovy coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 2ovy coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 72%
No. subunits : 1
Symmetry : None
More details
3DComplex & QSbio predictionx
No. subunits : Unclear
Symmetry : Unclear
Evidence : This biological assembly agrees with the prediction of EPPIC but not of PISA
Assembly 2
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: homo trimer
Accessible surface area: 38231.5 Å2
Buried surface area: 7621.69 Å2
Dissociation area: 2,023.09 Å2
Dissociation energy (ΔGdiss): 20.71 kcal/mol
Dissociation entropy (TΔSdiss): 27.73 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-193053
Homo trimeric assembly 2 of PDB entry 2ovy coloured by chemically distinct molecules, front view.
Homo trimeric assembly 2 of PDB entry 2ovy coloured by chemically distinct molecules, side view.
Homo trimeric assembly 2 of PDB entry 2ovy coloured by chemically distinct molecules, top view.
    Assembly 2
Confidence : 87%
No. subunits : 3
Symmetry : C3
More details
3DComplex & QSbio predictionx
No. subunits : Unclear
Symmetry : Unclear
Evidence : This biological assembly agrees with the prediction of PISA but not of EPPIC

Macromolecules

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Chain: A
Length: 362 amino acids
Theoretical weight: 41.66 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9QYJ6 (Residues: 452-794; Coverage: 43%)
Gene name: Pde10a
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ovy, assembly 1, front view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ovy, assembly 1, side view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 2ovy, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9QYJ6  
136250100150200250300350
 
100200300
UniProt
Q9QYJ6
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Secondary structure
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Early folding residue predictions
Ligand binding sites
Sequence conservation
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