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Crystal structure of the third KH domain of human Poly(C)-Binding Protein-2 in complex with C-rich strand of human telomeric DNA

X-ray diffraction
1.6Å resolution
PDB entry 2p2r coloured by chain, front view.
PDB entry 2p2r coloured by chain, side view.
PDB entry 2p2r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Poly(rC)-binding protein 2 and DNA
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Multimeric state: hetero dimer
Accessible surface area: 5269.28 Å2
Buried surface area: 1432.47 Å2
Dissociation area: 631.67 Å2
Dissociation energy (ΔGdiss): -5.93 kcal/mol
Dissociation entropy (TΔSdiss): 8.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115750

Macromolecules

Poly(rC)-binding protein 2
Chain: A
Length: 76 amino acids
Theoretical weight: 8.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15366 (Residues: 285-359; Coverage: 21%)
Gene name: PCBP2
Pfam: KH domain
InterPro:
CATH: K Homology domain, type 1
Poly(rC)-binding protein 2 in PDB entry 2p2r, assembly 1, front view.
Poly(rC)-binding protein 2 in PDB entry 2p2r, assembly 1, side view.
Poly(rC)-binding protein 2 in PDB entry 2p2r, assembly 1, top view.
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DNA chain B
Name: C-rich strand of human telomeric DNA
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.07 KDa
C-rich strand of human telomeric DNA in PDB entry 2p2r, assembly 1, front view.
C-rich strand of human telomeric DNA in PDB entry 2p2r, assembly 1, side view.
C-rich strand of human telomeric DNA in PDB entry 2p2r, assembly 1, top view.
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