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Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP

X-ray diffraction
1.4Å resolution
PDB entry 2pez coloured by chain, front view.
PDB entry 2pez coloured by chain, side view.
PDB entry 2pez coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
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Multimeric state: homo dimer
Accessible surface area: 15029.98 Å2
Buried surface area: 3636.12 Å2
Dissociation area: 756.54 Å2
Dissociation energy (ΔGdiss): -0.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.12 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-128876

Macromolecules

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Chains: A, B
Length: 179 amino acids
Theoretical weight: 19.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43252 (Residues: 51-226; Coverage: 28%)
Gene names: ATPSK1, PAPSS, PAPSS1
Pfam: Adenylylsulphate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 in PDB entry 2pez, assembly 1, front view.
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 in PDB entry 2pez, assembly 1, side view.
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 in PDB entry 2pez, assembly 1, top view.
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