› 2pnb

Solution NMR

STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

Released:
DOI: 10.2210/pdb2pnb/pdb
PDB entry 2pnb coloured by chain, front view.
PDB entry 2pnb coloured by chain, side view.
PDB entry 2pnb coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I, Waterfield MD, Campbell ID
Nature 358 684-7 (1992)
PMID: 1323062

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.15 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P23727 (Residues: 328-431; Coverage: 14%)
Gene name: PIK3R1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

25 review citations

Phosphoinositide kinases.
Fruman et al. (1998)
24 more

2 mentions without citation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Gabelli et al. (2010)
1 more