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STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

Source organism: Bos taurus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.1.137: Phosphatidylinositol 3-kinase

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Alternative Name(s):
  • 1-phosphatidylinositol 3-kinase
  • PI3-kinase
  • PtdIns-3-kinase
  • Type I phosphatidylinositol kinase
  • Type III phosphoinositide 3-kinase
  • Vps34p

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00017
Domain description: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
The deposited structure of PDB entry 2pnb contains 1 copy of Pfam domain PF00017 (SH2 domain) in Phosphatidylinositol 3-kinase regulatory subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR035022
Domain description: PI3K p85 subunit, N-terminal SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha

Structure domain

CATH CATH domain
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
The deposited structure of PDB entry 2pnb contains 1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Phosphatidylinositol 3-kinase regulatory subunit alpha. Showing 1 copy in chain A.
SCOP SCOP annotation
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
The deposited structure of PDB entry 2pnb contains 1 copy of SCOP domain 55551 (SH2 domain) in Phosphatidylinositol 3-kinase regulatory subunit alpha. Showing 1 copy in chain A.

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