› › Structure analysis

X-ray crystal structure of human Mcl-1 in complex with Bim BH3

X-ray diffraction
2Å resolution
PDB entry 2pqk coloured by chain, front view.
PDB entry 2pqk coloured by chain, side view.
PDB entry 2pqk coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero octamer
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 8506.4 Å2
Buried surface area: 2416.75 Å2
Dissociation area: 1,023.17 Å2
Dissociation energy (ΔGdiss): 17.12 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-163174
Assembly 2
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero octamer
Accessible surface area: 29827.02 Å2
Buried surface area: 13876.01 Å2
Dissociation area: 745.05 Å2
Dissociation energy (ΔGdiss): 10.05 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-163176
Assembly 3
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero octamer
Accessible surface area: 35734.5 Å2
Buried surface area: 7967.2 Å2
Dissociation area: 745.05 Å2
Dissociation energy (ΔGdiss): 9.82 kcal/mol
Dissociation entropy (TΔSdiss): 13.74 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-163176
Assembly 4
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 15640.29 Å2
Buried surface area: 6211.23 Å2
Dissociation area: 699.82 Å2
Dissociation energy (ΔGdiss): 42.34 kcal/mol
Dissociation entropy (TΔSdiss): 12.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-163175
Assembly 5
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 18594.08 Å2
Buried surface area: 3256.9 Å2
Dissociation area: 597.12 Å2
Dissociation energy (ΔGdiss): 34.08 kcal/mol
Dissociation entropy (TΔSdiss): 12.21 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-163175
Assembly 6
Download    3D Visualisation
Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 9892.1 Å2
Buried surface area: 1030.81 Å2
Dissociation area: 340.28 Å2
Dissociation energy (ΔGdiss): 28.23 kcal/mol
Dissociation entropy (TΔSdiss): 8.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-163174

Macromolecules

Induced myeloid leukemia cell differentiation protein Mcl-1
Chain: A
Length: 158 amino acids
Theoretical weight: 17.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 172-327; Coverage: 45%)
Gene names: BCL2L3, MCL1
Pfam: Apoptosis regulator proteins, Bcl-2 family
InterPro:
CATH: Blc2-like
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 2pqk, assembly 1, front view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 2pqk, assembly 1, side view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 2pqk, assembly 1, top view.
Molecule details ›

Search similar proteins

Bim BH3 peptide
Chain: B
Length: 29 amino acids
Theoretical weight: 3.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
InterPro: Bcl-x interacting, BH3 domain
Bim BH3 peptide in PDB entry 2pqk, assembly 1, front view.
Bim BH3 peptide in PDB entry 2pqk, assembly 1, side view.
Bim BH3 peptide in PDB entry 2pqk, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links