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Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form

Source organism: Moorena producens 19L
Biochemical function: catalytic activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

Reaction catalysed:
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Systematic name:
(S)-3-hydroxyacyl-CoA:NAD(+) oxidoreductase
Alternative Name(s):
  • 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
  • 3-L-hydroxyacyl-CoA dehydrogenase
  • 3-beta-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxyacetyl-coenzyme A dehydrogenase
  • 3-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxybutyryl-CoA dehydrogenase
  • 3-hydroxyisobutyryl-CoA dehydrogenase
  • 3-keto reductase
  • Beta-hydroxy acid dehydrogenase
  • Beta-hydroxyacyl CoA dehydrogenase
  • Beta-hydroxyacyl dehydrogenase
  • Beta-hydroxyacyl-coenzyme A synthetase
  • Beta-hydroxyacylcoenzyme A dehydrogenase
  • Beta-hydroxybutyrylcoenzyme A dehydrogenase
  • Beta-keto-reductase
  • Beta-ketoacyl-CoA reductase
  • L-3-hydroxyacyl CoA dehydrogenase
  • L-3-hydroxyacyl coenzyme A dehydrogenase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. CurF
The deposited structure of PDB entry 2q34 contains 1 copy of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in 3-hydroxyacyl-CoA dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018376
Domain description: Enoyl-CoA hydratase/isomerase, conserved site
Occurring in:
  1. CurF
IPR001753
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. CurF
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. CurF

Structure domains

CATH CATH domains
6.20.390.20
Class: Special
Architecture: Other non-globular
Topology: Light-harvesting Protein
Homology: Light-harvesting Protein
Occurring in:
  1. CurF
The deposited structure of PDB entry 2q34 contains 1 copy of CATH domain 6.20.390.20 (Light-harvesting Protein) in 3-hydroxyacyl-CoA dehydrogenase. Showing 1 copy in chain A.
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. CurF
The deposited structure of PDB entry 2q34 contains 1 copy of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in 3-hydroxyacyl-CoA dehydrogenase. Showing 1 copy in chain A.

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