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Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.

X-ray diffraction
2.56Å resolution
PDB entry 2qb0 coloured by chain, front view.
PDB entry 2qb0 coloured by chain, side view.
PDB entry 2qb0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endolysin and Transcription factor ETV6
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Multimeric state: hetero dimer
Accessible surface area: 17114.48 Å2
Buried surface area: 1610.0 Å2
Dissociation area: 673.16 Å2
Dissociation energy (ΔGdiss): -4.4 kcal/mol
Dissociation entropy (TΔSdiss): 11.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133024
Assembly 2
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Assembly Name: Endolysin and Transcription factor ETV6
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Multimeric state: hetero dimer
Accessible surface area: 16925.8 Å2
Buried surface area: 1737.56 Å2
Dissociation area: 670.99 Å2
Dissociation energy (ΔGdiss): -4.46 kcal/mol
Dissociation entropy (TΔSdiss): 11.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133024

Macromolecules

Transcription factor ETV6
Chains: A, C
Length: 77 amino acids
Theoretical weight: 9.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41212 (Residues: 47-123; Coverage: 17%)
Gene names: ETV6, TEL, TEL1
Pfam: Sterile alpha motif (SAM)/Pointed domain
InterPro:
CATH: Transcription Factor, Ets-1
SCOP: Pointed domain
Transcription factor ETV6 in PDB entry 2qb0, assembly 1, front view.
Transcription factor ETV6 in PDB entry 2qb0, assembly 1, side view.
Transcription factor ETV6 in PDB entry 2qb0, assembly 1, top view.
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Endolysin
Chains: B, D
Length: 241 amino acids
Theoretical weight: 27.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00720 (Residues: 2-162; Coverage: 98%)
Gene name: E
Pfam: Phage lysozyme
InterPro:
CATH:
Endolysin in PDB entry 2qb0, assembly 1, front view.
Endolysin in PDB entry 2qb0, assembly 1, side view.
Endolysin in PDB entry 2qb0, assembly 1, top view.
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